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Special Needs Research and News
Gainesville Music Therapy parents receive frequent e-mails with the articles of interest to the special needs community, including research on Autism, Down Syndrome, ADHD, etc.; conferences and trainings being offered in the local area; and information on music therapy practice. If you would like to receive these articles, and/or our monthly newsletter by e-mail, please e-mail us to join the mailing list.
Friday, November 24, 2006Music therapy may help schizophrenia8 Nov 2006Nick Gibbens Music therapy may improve some of the symptoms of schizophrenia, according to a new study. The research, which is published in the British Journal of Psychiatry, is the first time music therapy for people with acute schizophrenia has been evaluated. Researchers from Imperial College London and therapists from the Central and North West London Mental Health Trust conducted the study. In their small study, 81 in-patients at four hospitals in London were randomised to receive music therapy or standard care alone. Those people receiving music therapy had between 8 and 12 sessions, once a week, for up to 45 minutes. During the sessions patients were given access to a range of musical instruments and encouraged to use them to express themselves. Initially the therapist listened carefully to the patient's music and accompanied them closely, seeking to follow their emotional state in musical terms. The therapist then offered opportunities to extend or vary the nature of the musical interaction. The researchers measured symptoms of schizophrenia and found that improvements were greater among those people receiving music therapy than among those receiving standard care alone. Referral for music therapy was associated with reductions in general symptoms, such as depression and anxiety, and the negative symptoms of schizophrenia, such as emotional withdrawal. However, the researchers caution that because this was a small study, it is possible that other factors, such as severity of illness, may have influenced the study's findings. Lead researcher Dr Mike Crawford, from Imperial College London, said: "We have known for some time that psychological treatments can help people with schizophrenia, but these have only been used when people are fairly stable. "This study shows that music therapy provides a way of working with people when they are acutely unwell. "At such times patients may find it difficult to express themselves using words, but through the skill of the therapist it may be possible to help people interact through music in a way that is constructive, creative and enjoyable." Schizophrenia is a chronic, severe, and disabling brain disease. According to Schizophrenia.com, the condition affects about 1 per cent of people in the UK and the US. In 2002, the overall US cost of schizophrenia was estimated to be $62.7bn. permalink posted on 8:10 AM 0 comments
Mutated Gene more than doubles the risk of AutismMonday, October 16, 2006 (EST)Researchers find mounting evidence that genes play an important role in an individual’s susceptibility to autism. A single gene mutation can cause this complex disorder in children. Researchers have identified a common gene variant that more than doubles the risk of autism. A research led by Vanderbilt Kennedy Center reveals that a genetic variant associated with the MET gene is common in children with autism and appears more frequently in families that have more than one affected child. Although both environmental and genetic factors are likely involved in autism but researchers say there is mounting evidence that suggests that genes play an important role in an individual’s susceptibility to the disorder. Autism is characterized by varying degrees of impairment in communication skills, social interactions, and restricted, repetitive and stereotyped patterns of behavior. Children with the disorder can be accurately identified by the age of 1 year or even younger. Dr. Pat Levitt and colleagues at Vanderbilt University in Nashville, Tennessee analyzed the MET gene in more than 700 families who had at least one child with autism. They found that children with autism commonly had a specific change in the sequence of the promoter region of the gene, the part of the gene that regulates the amount of MET protein produced. Dr Levitt said, “Autism is recognized as the most highly heritable neuropsychiatric disorder. In identical twins, the concordance is between 70 percent and 90 percent, meaning that if one twin has autism, the other twin is at very high risk of having the disorder.” While the search for autism vulnerability genes has intensified in recent years, most studies have identified only linkage peaks, or areas on specific chromosomes where such genes might lie. Chromosome 7 contains several such “hotspots,” but few promising susceptibility genes have been identified in the region. While conducting research on genes involved in brain development in mice, Levitt’s team had found that the MET gene – a gene typically associated with cancer – was involved in the development of certain circuits within the cerebral cortex, a brain region whose development is disrupted in autism. “This gene also happens to be located in one of those ‘hotspots,’” Levitt said. Additionally, MET has known roles in the development of the cerebellum – another brain region implicated in autism – and in immune system regulation and gastrointestinal repair. Some children with autism exhibit medical problems related to those systems. Given these associations and MET’s chromosomal location, Levitt wondered if this gene could be involved in autism vulnerability. “This variant is in the part of the gene that controls how much of the gene gets expressed…kind of like ‘volume control’ on a stereo,” Levitt said. People with two copies of this variant were 2.27 times as likely to have autism as the general population. Individuals with only one copy were also at higher risk (1.67 times) than those without the variant. “This is a relatively common variant, seen in about 47 percent of the population,” Levitt said. “So why doesn’t everybody have autism?” That speaks to the environmental and other genetic contributions, Levitt said. “Genes create a vulnerability that then gets coupled with some environmental disturbance – but right now, we don’t have any idea what those factors might be.” But these findings do help set the stage for more in-depth investigation of the interaction between genes and environmental factors in animal models. Levitt is now creating animals with this genetic variant to assess environmental contributions and probe the underlying biology of autism. “This mutation itself is not going to be diagnostic,” he said. But if other genetic variations are identified that carry similar robust associations with autism, screening for a combination of these variants could facilitate the early identification of those at high risk of autism. And improving early diagnosis might be the best way to help treat or prevent the disorder. “The more genetic vulnerability genes we identify, the better handle we have on designing experiments to look at gene-environment interactions,” Levitt said. “We think this will be the way to understand autism and prevent it.” The finding are published in this week’s online edition of the Proceedings of the National Academy of Sciences. permalink posted on 8:09 AM 0 comments
Early Childhood TV Viewing May Trigger AutismAutism in Children and TV
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